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Single-nucleotide polymorphisms (SNPs) may cause a disease or predispose an individual to a disease. High-throughput screening of known SNPs in a large set of samples offers opportunities to study the impact of such variants on for example disease predisposition. At Biogazelle qPCR is applied for high-throughput targeted SNP genotyping in DNA.
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While SNP genotyping on a genome-scale is currently dominated by microarrays and to a lesser extent massively parallel sequencing, detection of a targeted selection of SNPs is mainly done by qPCR. qPCR using hydrolysis probes is the most commonly used PCR method for genotyping. Biogazelle offers medium and large-scale genotyping studies using TaqMan SNP Genotyping Assays.