Biomarker-driven gut inflammation diagnosis

Case Study

Gut inflammation is commonly present in arthritis patients, linked to extensive disease and representing an important risk factor for the development of Crohn’s disease. Gut inflammation is evaluated through colonoscopy, a disturbing test for patients. Seeking for alternatives to reduce the number of colonoscopies, we supported the research of Prof. Dirk Elewaut at the VIB towards the development of a blood-based test that can predict gut inflammation in arthritis patients.

Biogazelle’s contribution included the profiling of a large panel of miRNA biomarker candidates in serum samples from arthritis patients. A biomarker signature was identified and validated in a second, independent patient cohort, paving the path towards the development of an RT-qPCR test to be implemented in the clinic.

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