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Along with the (r)evolution of RNA sequencing technology, researchers began to understand that the transcriptome is not only composed of messenger RNA molecules that are being translated to proteins. A wide range of small and long non-coding RNAs have been detected and their gene regulatory role has been firmly documented. The latest databases provide a striking view to the complexity and extent of the human transcriptome. The complexity of an organism scales positively with the fraction of the non-coding part of the genome. The difference between a human and a worm for example is primarily explained by the large difference in number of expressed non-coding RNAs. Further, non-coding RNA genes have been shown to play an important role in various diseases.
Biogazelle offers a broad portfolio of targeted tests that can be applied on cell-free or circulating DNA for the detection and quantification of specific genomic aberrations. We summarized our expertise on RNA and DNA biomarkers in liquid biopsies in this infographic.